Avalanche Biotechnologies Header Image: Iris
Sustained Therapeutic delivery for the eye

Careers @ Avalanche

To apply for a position, please submit your resume to careers@avalanchebiotech.com. We're always looking for great people, so don't hesitate to submit your resume even if you don't see a specific position that matches your qualifications.


 


Director, Business Development

Department: Corporate Development                                       
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. The Director/Senior Director is responsible for Business Development. In conjunction with the VP Corporate Development and other cross-functional business partners is responsible for the identification, pursuit and acquisition of strategic business opportunities including mergers, acquisitions, partnerships, alliances, joint ventures, and licensing agreements that fit within the overall corporate strategy, business plan and product portfolio. In conjunction with senior leadership assists in the development of short and long-range strategic plans for Avalanche Biotechnologies.

Collaborates cross-functionally with team members (Research, Development, Regulatory, Commercial, Finance, Legal and other colleagues as appropriate) in the objective scientific and business assessment of 3rd party candidates in support of business opportunities. In conjunction with executive leadership, the position assists in the development and facilitation of product development strategic plan, identifying issues, and assisting in the implementation of solutions and the success of projects.

Essential duties and responsibilities include but are not limited to the following:   

  • Support business development through robust opportunity assessment, including financial valuation and analysis of system cost-savings potential.
  • Analyzes the attractiveness, feasibility and commercial viability of the opportunity for the company, proposing further action or rejection of the initiative.                                 
  • Interacts with the internal departments related with the project (Research, Administration, Finance, etc), outlines strategy and establishes the initial project Action Plan, working closely with the business unit Managers.                        
  • Supports the definition of the business structure and facilitates the development of necessary contacts with target and related stakeholders.                           
  • Presents new products and services to the management, carries out negotiations in those required cases with the relevant parties and manages required approval.                           
  • Coordinates the implementation, monitors performance, issues reports and makes necessary adjustments.
  • Implement and manage project changes and interventions to achieve project outputs.
  • Establish contacts with key external partners and look into the possibility of cooperation in specific segments.
  • Data collection, screening and analysis for specific business development topics addressing mid-long term business potentials and leveraging short term business benefit.
  • Perform market and industry research and analysis.
  • Monitor markets, industries and organizations of potential strategic interest.

Position Requirements and Experience:

  • Bachelor’s degree in a scientific discipline, Master’s/MBA degree in business/science preferred.
  • 12-15+ years experience in Pharma/Bio industry.
  • Knowledge of Pharmaceutical product development and relevant scientific technologies, outstanding skills in communication, negotiation, strategy, financing, business, economics, leadership, critical thinking and cross-functional partnering.
  • Interact with all levels of the company cross-functionally including the Executive Committee.  Also interacts with KOLs, vendors, community leaders, business, scientific and physician thought leaders.
  • Knowledge and proficiency in various database and computer business intelligence systems.
  • Experience in R&D, commercial, market research, or equivalent experience desirable.
  • Demonstrated negotiation skills.
  • Travel and conference and meeting attendance required.
  • PC literacy required; MSOffice skills (Outlook, Word, Excel, PowerPoint).

Research Scientist

Department: Research
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. This is a position for a highly innovative, passionate, and energetic Scientist to develop adeno-associated viral vector technologies for ophthalmic disease targets in an industry setting. The candidate should be extremely motivated to scientifically contribute to the dynamic research program at Avalanche Biotechnologies as well as assist other cross-functional teams when needed.

Essential duties and responsibilities include but are not limited to the following:

  • Pursue work with the goal of carrying out novel research of the highest quality to understand, improve, and advance Avalanche Biotech’s product pipeline.
  • Independently design and execute experiments following appropriate laboratory procedures and produce competent and reproducible results to a high technical standard.
  • Appropriately analyze data, interpret results, and maintain accurate records with minimum supervision.
  • Participate in the development of assays for the characterization of vector products.

Position Requirements and Experience:

  • The candidate should possess a Ph.D. in the Biomedical Sciences. The candidate should also have been productive and successful during his/her post-doctoral training.
  • A broad knowledge base in molecular biology, biochemistry, immunology, and gene therapy. Background in the area of retinal diseases is desired and understanding of AAV biology is favorable.
  • Have at least three first-author papers in peer-reviewed journals.
  • Expertise in a variety of laboratory techniques such as recombinant DNA technology, including qPCR, vectorology, DNA/RNA isolation and analysis; sterile tissue culture techniques; biochemical techniques including, Western Blot, flow cytometry, immunofluorescence, and ELISA.
  • Experience with ocular in vivo animal models is preferred and know-how with the baculovirus expression system is a plus.
  • Qualified candidates should be detail oriented and have good time management skills.
  • Must be proactive, co-operative, and willing to work in a small team environment.
  • Have excellent verbal and written communication skills.
  • Be proficient with MS Office and other commonly used software.

Senior Medical Writer

DepartmentDevelopment
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. The Senior Medical Writer is responsible for managing all aspects of the writing and editing of clinical, regulatory, and scientific documents for publication and submission to regulatory agencies (US and ex-US). 

Essential duties and responsibilities include but are not limited to the following:

  • Write, edit, prepare and coordinate the production of a broad scope of documents (e.g. Investigator Brochures, clinical protocols, clinical study reports (CSRs), CSR narratives, and other documents for submission to regulatory agencies and prepares other regulatory and clinical trial documentation as necessary.
  • Serve as primary technical writer for abstracts, posters, presentations, and manuscripts for submission to scientific conferences and peer-reviewed journals.
  • Serve as a key cross-functional point of contact for clinical, preclinical, CMC, regulatory, and scientific staff to obtain analytical information and proprietary data, and synthesize into holistic and coherent narrative documents.
  • Compile, analyze, and summarize data from statistical tables and other sources as needed.
  • Establish, prepare and maintain corporate document standards, styles and formats to create professional and cohesive documents (i.e., margin widths, font style and size, header style and size, headings and subheadings, table and figure formats and styles).
  • Prepare graphic presentations using graphic software applications.
  • Manage various projects simultaneously and maintain timelines for document completion (from conception to final signature).
  • Primary company interface with eCTD preparation and submission vendor.
  • Manage internal and external medical writers and oversee medical writing project budgets, expenditures, and payments to multiple consultants.
  • Keep abreast of professional information and technology through literature or conferences.

Position Requirements and Experience:

  • Advanced degree in a scientific discipline, or in English or Journalism (with additional science coursework), or equivalent, and 5+ years experience as a technical writer at a leading biotech/pharmaceutical company.
  • Experience in preparation of clinical/regulatory documents for US and non-US regulatory submissions required (e.g., Clinical Protocols, INDs, NDAs, BLAs, CTDs).
  • Excellent written communication.
  • Highly detail-oriented and self-motivated, with excellent follow-through.
  • Experience in preparation of Preclinical/CMC documents is a desired plus.
  • Familiarity with therapeutic area of ophthalmology/retina is desirable.
  • Experience managing vendors and project budgets required.
  • Strong analytical and business communication skills.
  • Experience in eCTD preparation & submission a plus.
  • Proven experience in using negotiating, influencing, and problem-solving skills in order to meet document timelines.
  • Experience using Microsoft Word, Excel, PowerPoint, EndNote and Adobe Photoshop required.

Project Manager

Department: Clinical
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. The Project Manager will be accountable for managing projects to successful and timely decision points from late stage research through clinical development. The Project Manager will contribute to the definition of project strategy and guide the project team to deliver on project objectives.This position will be accountable for steering drug development teams through corporate processes, both internally and together with collaborators.

Essential duties and responsibilities include but are not limited to the following:

  • Serve as the principal driver of R&D projects by ensuring timely deliverables from project teams.
  • Facilitate project team meetings, cross-functional communication and decision- making, ensuring alignment with internal and external stakeholders.
  • Schedule and organize meetings; generating agendas and minutes; distributing materials for review; communicating deadlines; following up on action items; tracking decisions and progress; coordinating and documenting approvals; and maintaining a repository of approved materials.
  • Closely and transparently manage the critical path and rate-limiting steps of multiple development projects.
  • Collaborate with cross-functional stakeholders to identify strategic and operational risks to timelines and deliverables to create appropriate mitigation and contingency plans.

Position Requirements and Experience:

  • Excellent interpersonal skills, including clear, succinct and timely communication and proven ability to foster important relationships with customers and key stakeholders.
  • A minimum of 5 years in biotech/pharmaceutical industry, with 2+ years of Project Management experience.
  • Excellent oral and written communications skills.
  • Excellent organizational skills, with ability to successfully manage multiple priorities.
  • Strong influencing skills:  proven ability to get things done without formal authority.
  • Ability to work effectively with cross-functional teams.
  • Late stage drug development and Regulatory (NDA) submission experience preferred.
  • Ophthalmology / retina experience is preferred.
  • Highly proficient in MS Office Suite and project management software (Word, Excel, MS Project, PowerPoint).
  • Highly self-motivated and detail-oriented, with proven ability to work independently.
  • Bachelor’s Degree in life sciences required; advanced degree is a plus.
  • PMP (project management professional) certification or equivalent is a plus.

Contract Administrator

Department: Legal
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. Avalanche Biotech is currently seeking a qualified, highly motivated, experienced paralegal for the position of Contracts Administrator. This position will report to the VP Legal and Corporate Development. Attorney candidates will not be considered. 

This position requires a self-motivated, flexible candidate who likes a challenge, with excellent interpersonal skills and ability to manage changing priorities and a range of job functions. Perform all functions with a high level of accuracy, accountability and initiative. Work as a team member on a daily basis.

Essential duties and responsibilities include but are not limited to the following:

  • Legal negotiations with vendors for clinical trials, contract research, and other services as needed.
  • Analyzes estimates of material equipment and production costs.
  • Reviews contractual documents to ensure adherence to company policy, government specifications and requirements, and conformance to master agreements.
  • May negotiate licensing agreements including renewal, new business and invoicing.
  • Anticipates problems and initiates actions.
  • Participate in client calls to explain our contracts and negotiate terms in support of our business.
  • Manage pre-execution and post-execution contracts and reporting in the department’s contract management system.
  • Project Tracking.
  • Support data information requests by attorneys and business teams and respond to complex inquiries regarding contract obligations and revisions
  • Other duties assigned.

Position Requirements and Experience:

  • Experience in legal contract negotiation with both standard and non-standard contract terms.
  • Strong negotiation skills.
  • Excellent time management and organizational skills required.
  • Strong computer skills required (Outlook, Word, and Excel).
  • Able to take direction and work independently, prioritize and multi-task in a fast-paced environment.
  • Analytical and detail oriented.
  • Practical and proactive problem solver.
  • Comfortable working with different levels of the company including senior level management.
  • Minimum 5 years contract management experience in the pharmaceutical or medical device industry.
  • Paralegal certificate preferred.

Business Development Analyst

Department: Corporate Development
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. The Bushiness Development Analyst will help identify, develop and implement business opportunities aiming at increasing revenues. Analyze potential, establish contacts, support definition of required resources, liaise with internal departments, carry out negotiations and field research, prepare the business plan and seeks corresponding approvals.

Essential duties and responsibilities include but are not limited to the following:

  • Support business development through robust opportunity assessment, including financial valuation and analysis of system cost-savings potential.
  • Analyzes the attractiveness, feasibility and commercial viability of the opportunity for the company, proposing further action or rejection of the initiative.                                  
  • Interacts with the internal departments related with the project (Research, Administration, Finance, etc), outlines strategy and establishes the initial project Action Plan, working closely with the business unit Managers.                       
  • Supports the definition of the business structure and facilitates the development of necessary contacts with target and related stakeholders.                            
  • Presents new products and services to the management, carries out negotiations in those required cases with the relevant parties and manages required approval.                           
  • Coordinates the implementation, monitors performance, issues reports and makes necessary adjustments.
  • Implement and manage project changes and interventions to achieve project outputs.
  • Establish contacts with key external partners and look into the possibility of cooperation in specific segments.
  • Data collection, screening and analysis for specific business development topics addressing mid-long term business potentials and leveraging short term business benefit.
  • Perform market and industry research and analysis.
  • Monitor markets, industries and organizations of potential strategic interest.

 Position Requirements and Experience:

  • Bachelor Degree or higher in Life Science or related disciplines.
  • 2+ years working in finance, business development, consulting and/or strategic planning roles; experience in Pharma/Bio industry required.
  • Advanced data and financial analysis skills; investment banking, consulting, payer/provider or health economics backgrounds, a plus.
  • Strong analytical and strategic thinking skills.
  • Excellent verbal and written communications skills; ability to present ideas creatively and with impact.
  • Ability to interact and collaborate with all levels of management and cross-functional teams.
  • Ability to perform under pressure and in a very dynamic environment with a high degree of initiative and motivation.

QC Analyst

Department: Development
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. The QC analyst is responsible for performing analytical testing on Avalanche’s research and clinical grade products for characterization, release and stability. 

Essential duties and responsibilities include but are not limited to the following:

  • Perform daily QC testing activities to support the research, development, manufacture and release of phase I/II adeno-associated virus-based gene therapy products following cGMP and written SOP’s.
  • Analyze samples for multiple types of cell based bio-assays (potency, infectivity, expression of proteins), ELISA’s, Western Blots, SDS-PAGE, molecular assays (e.g., qPCR) per SOP’s for QC lot release, stability, and research and development samples.
  • Deliver timely, accurate and reliable sample testing results following standard operating procedures in a GMP laboratory.
  • Develop and optimize existing assays from analytic development into a QC environment; and troubleshoot existing assays.
  • Generate and qualify critical reagents for use over time, and trending their performance.
  • Follow good documentation practices, including recording critical assay parameters, basic equipment usage, method qualification, investigations of OOS results, and trending data.
  • Identify problems, communicate them to the team, and develop solutions.

 Position Requirements and Experience:

  • BS/MS degree in a scientific discipline with 5 yrs. of industrial experience.
  • 5-8 yrs. experience required within a cGMP controlled environment.
  • Assay qualification and validation experience preferred.
  • In depth knowledge of statistical methods for the analysis of experimental data.
  • Experience with virus based biologics, and AAV gene therapy product experience required.
  • Excellent command of scientific fundamentals, and can translate that into their laboratory work and advanced testing techniques.
  • Creative thinker with hands-on attitude and innovative approach to problem solving outside of their comfort-zone and learn on-the-fly if necessary.
  • Energetic, goal-oriented analyst who can work in a multidisciplinary environment using chemical and biological approaches to QC assays.
  • Good interpersonal skills and the ability to work independently as well as within interdisciplinary teams.
  • Must be highly organized, detail-oriented and able to manage multiple tasks concurrently
  • Excellent written and oral communication skills
  • Proficient with common Office and equipment software (MSWord, Excel, Powerpoint, Softmax Pro, FlowJo, etc.)

Research Associate-Assay Development

Department: Research
Status: Full time

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. The job responsibility will fall under Pharmaceutical Development Group’s Assay Development team that supports research and product development aimed at developing adeno-associated vector products for pre-clinical or clinical applications. 

This position will support the development of in vitro assays for discovery and characterization to enable selection of candidates for drug development. It will primarily function in developing biochemical/ immunochemical, cell-based assays as in vitro tools for preclinical pipeline products.  Additional responsibilities may include testing in support of AAV vector characterization for process development and lot release according to established test procedures.

Essential duties and responsibilities include but are not limited to the following:

  • Execute assigned tasks following appropriate laboratory/technical procedures under minimal supervision.
  • Assist with the investigation, creation and development of methods, experiments and / or technologies.
  • Make detailed observations and analyze data to provide an interpretation of results.
  • Prepare technical reports, summaries, protocols, and / or quantitative analyses.
  • Present data in group and project team meetings.
  • Produce competent, reproducible results to a high technical standard.
  • Maintain accurate and well-organized laboratory records and note books.

 Position Requirements and Experience:

  • BS/BA or MS (3-5 years) relevant experience in bio-pharma R&D, process development or assay development group.
  • 3 years’ experience in mammalian aseptic cell culture techniques is required.
  • 1-2 years’ experience in developing/performing cell based and biochemical/immunochemical assays is required (ELISAs, SDS/PAGE, Western blot etc.).
  • General molecular biology skills (DNA/RNA isolation and analysis, PCR/QPCR) and flow cytometry is preferred.
    • Must be detail-oriented with good organization and time management skills.
    • Excellent verbal and written communication skills.
    • Willingness to take on multiple responsibilities and work in small team environment.
    • Proficiency with MS Office and common laboratory software (SoftmaxPro, GraphPad Prism, etc.

Administrative Assistant

Department: General and Administrative
Status: Full Time Temp to Regular/Non-Exempt

Summary: Avalanche develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat ophthalmologic disorders. If you are a dynamic person who demonstrates a hands on, can do attitude, willing to wear multiple hats then we have the perfect position for you! The Administrative Assistant will provide essential administrative support for a rapidly growing start up.

Essential duties and responsibilities include but are not limited to the following:

  • Manage calendars, schedule meetings for VP and senior management team.
  • Support corporate travel including making travel arrangements.
  • Support legal and CMC departments including filing, document control, and archiving.
  • Manage office supplies and implement cost reductions.
  • Keep reception area and common areas of the office tidy.
  • Coordinate and arrange meals for VP or other in-office catering on as-needed basis.
  • Manage laboratory equipment inventory system and equipment maintenance requirements.
  • Front office reception.
  • Answer telephone calls coming to main office line.
  • Research and advice senior management team solutions to add value to the administrative process.
  • Implement and manage special projects to completion with minimal supervision as needed.

Position Requirements and Experience:

  • High level of professionalism.
  • Excellent written and oral communication skills.
  • Ability to be highly responsive with rapid turnaround time.
  • Self-starter with ability to learn new disciplines.
  • Able to consistently demonstrate flexibility and positive attitude in a dynamic, entrepreneurial setting.
  • Good command of MS Word, Outlook, Excel, and PowerPoint.
  • College degree preferred but is not required.